It was a star studded night in Denver on Thursday when Barack Obama rocked the Democratic Convention with his moving speech.
"Just seeing him on stage, I cried my eyelashes off," Winfrey told Entertainment Tonight backstage.
"I've never experienced anything like this... I think that what he had to offer the country tonight will make us all better," she added.
Kanye West then stepped into the interview and agreed, saying, "It changed my life."
Check out the clip below of Queen O and Kanye responding to Obama's acceptance speech. What did you think of his speech? And which candidate are you planning on voting for?