More than 13,000 people showed up to a taping in Chicago for the final show, which will air on May 23 and 24, ahead of the last episode on May 25.
Tom Cruise, who clearly just had to say goodbye to Oprah’s couch one last time, told the audience: "You have always had the power to change lives. And that is the lesson you brought."
Lesson: Don’t jump on Oprah’s couch and make a fool of yourself.
Madonna revealed she admired Oprah because she was a "self made woman" who has shown people that hard work and determination pay off.
She said: "It's no secret that millions of people are inspired by Oprah. She's a self-made woman who's been at the top of her game for over 25 years and she is still kicking ass and encouraging people to dream big to work hard, to read a book, to ask questions, to get an education no matter who you are or where you come from."
Ditto Madge, ditto.
And the guest who is making the most headlines—Maria Shriver. Speaking to Oprah, Maria said: "You have given me love, support, wisdom and most of all truth."
Jamie Foxx serenaded Oprah with a version of 'Isn't She Lovely', Stevie Wonder rose up from under the stage to perform a new track he had written specifically for her.
Beyonce Knowles also sang her new hit 'Run the World (Girls)', while Josh Groban and Patti LaBelle sang 'Over the Rainbow' from 'The Wizard of Oz'.
Damn, now that’s what I call going out with a bang!