"Almost a million people a year die of Malaria, and out of that number 85% die under the age of Justin Bieber," John says with a serious face. "Next year we'll go Jonas Brothers," he jokingly added.
A slew of celebs are then featured asking folks to donate $10, which is the cost of one Malaria net.
A spokesman for the campaign said: “Every 45 seconds a child dies in Africa from malaria but humor can keep malaria in the spotlight and in the conversation too.”
The video is hilarious, but the cause is serious. To donate money or learn more check out MalariaNoMore.org or text "NET" to 85944.