The Samantha Who? star had a turbulent year, with her public battle with breast cancer, and the loss of her good friend. But she's now not only happy and healthy, she's on top of the world.
Applegate credits her new boyfriend, Dutch bass player Martyn Lenoble, for the dramatic change in her life and attitude.
"I'm very grateful to Martyn for coming along at a time that he did because he's been my rock through all of this," Applegate says. "He gave me something to really want to live for and something to smile about."
And what a smile it is! She may the quirky, funny girl we've all grown to love, but Christina insists that wasn't always the case. "I used to be really shy but I started to come into my own in my late 20s and early 30s."
"Now I'm not afraid to speak up in a room full of people and be a part of the conversation," she adds.
So who else made the cut? You shouldn't be too surprised with the number two pick, Halle Berry. When asked what makes her face so beautiful, Halle said:
"My daughter's smile and her eight new teeth, the smell of fresh flowers, hiking as the sun comes up, feeling good about the woman I’ve become and finally getting a complete night of sleep."
Rounding out the top three are the pretty young thangs of 90210. Jessica Stroup, 22, AnnaLynne McCord, 21, Jessica Lowndes, 20, and Shenae Grimes, 19 – put their best, freshest faces forward for their shoot.
You can check out the list of the most beautiful people here. Do you agree with their most beautiful pick? If not, who would you choose for the cover?